Manuscripts
Writing & editing scientific research articles
Discovery of Novel SIK2/3 Inhibitors for the Potential Treatment of MEF2C+ Acute Myeloid Leukemia (AML)
Journal of Medicinal Chemistry, 20 March 2025
Wei Zhu, Pei Zhao, Tingting Liu, Feng Gao, Qi Li, Xin Cai, Man Zhang, Alex Aliper, Feng Ren, Alex Zhavoronkov, Xiao Ding
AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
Aging & Disease, 17 Feb 2025
Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov
Discovery of pyrrolopyrimidinone derivatives as potent PKMYT1 inhibitors for the treatment of cancer
European Journal of Medicinal Chemistry, 5 Jan 2025
Chao Wang, Yazhou Wang, Fanye Meng, Tingting Liu, Xiaomin Wang, Xin Cai, Man Zhang, Alex Aliper, Feng Ren, Alex Zhavoronkov, Xiao Ding
Discovery of Pyrrolopyrazine Carboxamide Derivatives as Potent and Selective FGFR2/3 Inhibitors that Overcome Mutant Resistance
Journal of Medicinal Chemistry, 31 Jan 2025
Yazhou Wang, Yihong Zhang, Jinxin Liu, Jichen Zhao, Chao Wang, Fanye Meng, Xin Cai, Man Zhang, Alex Aliper, Tao Liang, Feng Yan, Feng Ren, Jiong Lan, Qiang Lu, Fusheng Zhou, Alex Zhavoronkov, Xiao Ding
Intestinal mucosal barrier repair and immune regulation with an AI-developed gut-restricted PHD inhibitor
Nature Biotechnology, 11 Dec 2024
Yanyun Fu, Xiao Ding, Man Zhang, Chunlei Feng, Ziqi Yan, Feng Wang, Jianyu Xu, Xiaoxia Lin, Xiaoyu Ding, Ling Wang, Yaya Fan, Taotao Li, Yushu Yin, Xing Liang, Chenxi Xu, Shan Chen, Fadi E. Pulous, David Gennert, Frank W. Pun, Petrina Kamya, Feng Ren, Alex Aliper & Alex Zhavoronkov
TNIK's emerging role in cancer, metabolism, and age-related diseases
Trends in Pharmacological Sciences, 21 May 2024
Collin Y. Ewald, Fadi E. Pulous, Sarah Wing Yan Lok, Frank W. Pun, Alex Aliper, Feng Ren, Alex Zhavoronkov
